We use cookies to ensure you get the best experience on our website
首頁 探索 說明 News
註冊 登入
doi
/
ADRDSulfides
派生自 klofton/ADRDSulfides
DOI
10.12751/g-node.l4e76c
1
0
複刻 0
Files

Elevated Sulfides are associated with Cognitive Dysfunction and Brain Atrophy in Alzheimer’s Disease and Related Dementias

分支: master
分支列表 標籤列表
ADRDSulfides
Katelyn Lofton 6dd60278c8 Update 'datacite.yml' 1 年之前
sub-A016 95eb80cb79 Upload files to 'sub-A016' 1 年之前
sub-A101 948668e88f Upload files to 'sub-A101' 1 年之前
sub-A111 e967751dbe Upload files to 'sub-A111' 1 年之前
sub-C035 af48adc84f Upload files to 'sub-C035' 1 年之前
sub-C043 7c8d3d38d1 Upload files to 'sub-C043' 1 年之前
sub-C104 9d9fa3281e Upload files to 'sub-C104' 1 年之前
sub-C105 94c974611e Upload files to 'sub-C105' 1 年之前
sub-C106 bd4c35326b Upload files to 'sub-C106' 1 年之前
sub-C107 11af9e64ef Upload files to 'sub-C107' 1 年之前
sub-C109 927b64db78 Upload files to 'sub-C109' 1 年之前
sub-C110 0557c839e4 Upload files to 'sub-C110' 1 年之前
sub-C116 7bf04f6ddb Upload files to 'sub-C116' 1 年之前
sub-C117 2bceadf954 Upload files to 'sub-C117' 1 年之前
sub-C119 ae0ec57f5d Upload files to 'sub-C119' 1 年之前
sub-C123 b1ecaea9a1 Upload files to 'sub-C123' 1 年之前
sub-C124 6de4fa7db2 Upload files to 'sub-C124' 1 年之前
sub-C125 78eb16a982 Upload files to 'sub-C125' 1 年之前
sub-C126 b67835ce0e Upload files to 'sub-C126' 1 年之前
sub-C127 d685dd126e Upload files to 'sub-C127' 1 年之前
sub-C138 5c901cf72e Upload files to 'sub-C138' 1 年之前
sub-C140 2931e8b93f Upload files to 'sub-C140' 1 年之前
sub-C141 069d5f3e29 Upload files to 'sub-C141' 1 年之前
sub-C142 ff0cec0005 Upload files to 'sub-C142' 1 年之前
sub-C144 faba12524d Upload files to 'sub-C144' 1 年之前
sub-C145 f9ca83ae01 Upload files to 'sub-C145' 1 年之前
sub-C147 f7cb3cea63 Upload files to 'sub-C147' 1 年之前
sub-C149 e917a9c77b Upload files to 'sub-C149' 1 年之前
sub-C151 f4aed590ca Upload files to 'sub-C151' 1 年之前
LICENSE 09b7920bc4 Initial commit 1 年之前
README.md 0f00c44ea4 Update 'README.md' 1 年之前
datacite.yml 6dd60278c8 Update 'datacite.yml' 1 年之前

README.md

ADRDSulfides

Neuroimaging dataset for "Elevated Sulfides are associated with Cognitive Dysfunction and Brain Atrophy in Alzheimer’s Disease and Related Dementias". Contains T1, FLAIR, and DTI images for each subject in BIDS format.

datacite.yml
Title Elevated Sulfides are associated with Cognitive Dysfunction and Brain Atrophy in Alzheimer's Disease and Related Dementias
Authors Reekes,Tyler H.;Louisiana State University Health Shreveport;ORCID:0000-0003-4131-1094
Ledbetter,Christina R.;Louisiana State University Health Shreveport;ORCID:0000-0001-8581-6065
Pardue,Sibile;Louisiana State University Health Shreveport;ORCID:0000-0002-5133-7901
Alexander,J. Steven;Louisiana State University Health Shreveport;ORCID:0000-0001-6975-3711
Stokes,Karen Y.;Louisiana State University Health Shreveport;ORCID:0000-0002-7612-3467
Bhuiyan,Mohammad Alfrad Nobel;Louisiana State University Health Shreveport;ORCID:0000-0002-6011-2624
Patterson,James C.;Louisiana State University Health Shreveport;ORCID:0000-0001-5709-2557
Lofton,Katelyn T.;Louisiana State University Health Shreveport;ORCID:0000-0001-9620-1162
Kevil,Christopher G.;Louisiana State University Health Shreveport;ORCID:0000-0003-0863-7260
Disbrow,Elizabeth A.;Louisiana State University Health Shreveport;ORCID:0000-0002-2133-3221
Description Emerging evidence indicates that vascular stress is an important contributor to the pathophysiology of Alzheimer's disease and related dementias (ADRD). Hydrogen sulfide (H2S) and its metabolites (acid-labile (e.g., iron-sulfur clusters) and bound (e.g., per-, poly-sulfides)) have been shown to regulate both vascular and neuronal homeostasis. We recently reported that elevated plasma sulfides were associated with cognitive dysfunction and microvascular disease in ADRD; here we extend our previous work to show associations between elevated sulfides and magnetic resonance-based metrics of brain atrophy and white matter integrity. Elevated bound sulfides were associated with decreased measures of gray matter volume, while increased acid labile sulfides were associated with measures of decreased white matter integrity and increased ventricular volume. These findings are consistent with a ‘toxic’ sulfide model of ADRD. Our results are consistent with a compensatory sulfide response to oxidative stress.
License Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/)
References Reekes, T. H., Ledbetter, C. R., Pardue, S., Alexander, J. S., Stokes, K. Y., Bhuiyan, M. A. N., Patterson, J. C., Lofton, K. T., Kevil, C. G., & Disbrow, E. A. (2023). Elevated Sulfides are associated with Cognitive Dysfunction and Brain Atrophy in Alzheimer’s Disease and Related Dementias. Submitted to Redox Biology. [doi::tba] (IsSupplementTo)
Funding NIH, 3P2012130701A1S1
NIH, HL149264-01A1
Keywords Alzheimer's Disease
hydrogen sulfide
dementia
cortical thickness
white matter integrity
neuroimaging
Resource Type Dataset