Omission responses in local field potentials in rat auditory cortex

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auksztulewicz_harper_etal_omissions_bmcbiol

Omission responses in local field potentials in rat auditory cortex

Ryszard Auksztulewicz [1,2,3], Vani Gurusamy Rajendran [2], Fei Peng [2], Jan Wilbert Hendrik Schnupp [2], Nicol Spencer Harper [4]

[1] Center for Cognitive Neuroscience Berlin, Free University Berlin, Berlin, Germany [2] Dept of Neuroscience, City University of Hong Kong, Hong Kong S.A.R. [3] European Neuroscience Institute Göttingen - A Joint Initiative of the University Medical Center Göttingen and the Max Planck Society, Göttingen, Germany [4] Dept of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

Corresponding authors: ryszard.auksztulewicz@fu-berlin.de, nicol.harper@dpag.ox.ac.uk

Scripts reproduce Figures 2-5 based on data available in the "data" folder. Plotting uses helper scripts available in the "scripts/helper" folder.

datacite.yml
Title	Omission responses in local field potentials in rat auditory cortex
Authors	Auksztulewicz,Ryszard;Center for Cognitive Neuroscience Berlin, Free University Berlin, Berlin, Germany Rajendran,Vani;Dept of Neuroscience, City University of Hong Kong, Hong Kong S.A.R. Peng,Fei;Dept of Neuroscience, City University of Hong Kong, Hong Kong S.A.R. Schnupp,Jan;Dept of Neuroscience, City University of Hong Kong, Hong Kong S.A.R. Harper,Nicol;Dept of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Description	Non-invasive recordings of gross neural activity in humans often show responses to omitted stimuli in steady trains of identical stimuli. This has been taken as evidence for the neural coding of prediction or prediction error. However, evidence for such omission responses from invasive recordings of cellular-scale responses in animal models is scarce. Here, we sought to characterise omission responses using extracellular recordings in the auditory cortex of anaesthetised rats. We profiled omission responses across local field potentials (LFP), analogue multiunit activity (AMUA), and single/multi-unit spiking activity, using stimuli that were fixed-rate trains of acoustic noise bursts where 5% of bursts were randomly omitted. Significant omission responses were observed in LFP and AMUA signals, but not in spiking activity. These omission responses had a lower amplitude and longer latency than burst-evoked sensory responses, and omission response amplitude increased as a function of the number of preceding bursts. Together, our findings show that omission responses are most robustly observed in LFP and AMUA signals (relative to spiking activity) but do not show evidence for low-frequency phase locking. This has implications for models of cortical processing that require many neurons to encode prediction error in their spike output.
License	Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/)
References	Omission responses in field potentials but not spikes in rat auditory cortex. Ryszard Auksztulewicz, Vani Gurusamy Rajendran, Fei Peng, Jan Wilbert Hendrik Schnupp, Nicol Spencer Harper. bioRxiv 2022.02.11.479668; doi: https://doi.org/10.1101/2022.02.11.479668 [doi:10.1101/2022.02.11.479668] (IsSupplementTo) Omission responses in local field potentials in rat auditory cortex. Ryszard Auksztulewicz, Vani Gurusamy Rajendran, Fei Peng, Jan Wilbert Hendrik Schnupp, Nicol Spencer Harper. BMC Biology (in press) [doi:tba] (IsSupplementTo)
Funding	European Commission; 750459 Hong Kong General Research Fund; 11100518 European Community/Hong Kong Research Grants Council Joint Research Scheme; 9051402 Wellcome Trust; WT09975MA Wellcome Trust; WT108369/2015/Z
Keywords	Neuroscience Auditory Cortex Rat Omission response Predictive processing
Resource Type	Dataset

README.md

auksztulewicz_harper_etal_omissions_bmcbiol