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- # This CITATION.cff file was generated with cffinit.
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- cff-version: 1.2.0
- title: 'CRC C01'
- message: 'Identification and selective stimulation of motor recovery-related functional networks after experimental stroke'
- type: dataset
- authors:
- - given-names: Markus
- family-names: Aswendt
- email: markus.aswendt@uk-koeln.de
- affiliation: Group leader
- orcid: 'https://orcid.org/0000-0003-1423-0934'
- - given-names: Michael
- family-names: Schroeter
- email: michael.schroeter@uk-koeln.de
- affiliation: 'University of Cologne, Faculty of Medicine and University Hospital Cologne, Dept. of Neurology, Cologne, Germany'
- - given-names: Maria Adele
- family-names: Rüger
- email: maria.rueger@uk-koeln.de
- affiliation: 'University of Cologne, Faculty of Medicine and University Hospital Cologne, Dept. of Neurology, Cologne, Germany'
- - given-names: Aref
- family-names: Kalantari
- email: aref.kalantari-sarcheshmeh@uk-koeln.de
- affiliation: 'University of Cologne, Faculty of Medicine and University Hospital Cologne, Dept. of Neurology, Cologne, Germany'
- orcid: 'https://orcid.org/0000-0003-3050-0930'
- - given-names: Susan
- family-names: Vlachakis
- email: susan.vlachakis@uk-koeln.de
- affiliation: 'University of Cologne, Faculty of Medicine and University Hospital Cologne, Dept. of Neurology, Cologne, Germany'
- orcid: 'https://orcid.org/0000-0002-9429-2475'
- - given-names: Stefan
- family-names: Blaschke
- email: stefan.blaschke@uk-koeln.de
- affiliation: 'University of Cologne, Faculty of Medicine and University Hospital Cologne, Dept. of Neurology, Cologne, Germany'
- orcid: 'https://orcid.org/0000-0003-1423-0934'
- abstract: >-
- At the interface between cell biology and systems neuroscience, Project C01 (M. Adele Rüger, Markus Aswendt, Michael Schroeter) aims at
- providing mechanistic insights into spontaneous motor recovery after stroke and the effects of non-invasive transcranial direct current
- stimulation (tDCS) in a photothrombosis mouse model. The work program of this translationally oriented project combines information at
- the cellular (histology) and network level (rs-fMRI, DTI) to differentiate predictors of good versus poor motor recovery and associations
- with the response to tDCS. The novel approach includes optimization of the tDCS protocol with simultaneous electrocorticography (ECoG) in
- close collaboration with B01 (D. Isbrandt, J. Roeper) to establish tDCS for inducing motor recovery. Furthermore, network modelling strategies
- based on multimodal imaging and ECoG data will be used to predict motor behaviour and -recovery in close interaction – on both the conceptual
- and the methodological level – with the clinical project C05 (C. Grefkes, G.R. Fink). On the cellular level, the project focuses on the tDCS
- effects on neural stem cells and neuroinflammation, including experiments to rule out a causal relationship between spontaneous vs. tDCS-induced
- microglia activation underlying motor recovery after stroke.
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